Her bid to make Scotland the first part of the UK to change the law was defeated 85-16 in a free vote that allowed MSPs to vote with their consciences and not along party lines.
Ms MacDonald said the outcome was what she had expected.
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MSPs reject Bill legalising the right to die
Margo MacDonald has pledged she will try again to legalise assisted suicide if she is re-elected to the Scottish Parliament, after her controversial End of Life Assistance Bill was overwhelmingly rejected by MSPs.
