West Midlands Ambulance Service (WMAS) said the three children - two boys and one girl - were travelling in a vehicle on the M6 that had crashed and overturned.
They suffered serious injuries and could not be saved, a spokesman said.
Three children have died and two adults have been injured following a crash on a busy motorway.
West Midlands Ambulance Service (WMAS) said the three children - two boys and one girl - were travelling in a vehicle on the M6 that had crashed and overturned.
They suffered serious injuries and could not be saved, a spokesman said.
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