Just days after a deadly Taliban attack on Karachi airport, two top government officials said the drone strikes were carried out this week as a co-ordinated "joint Pakistan-US operation".
Military sources said six militants including four Uzbeks were killed in the first strike on Wednesday north of Miranshah, the capital of the North Waziristan tribal region where Taliban insurgents are holed up.
The second attack killed four militants in the same area around early yesterday.
The strikes are the first in the nuclear-armed South Asian nation since an attack in December last year in which three suspected militants were killed.
At least 38 people were killed when militants raided Karachi airport on Sunday night, an attack which all but destroyed hopes for a peace settlement with the Taliban.