RJ Reynolds Tobacco executive J Jeffery Raborn said the damages awarded to widow Cynthia Robinson by a Pensacola jury were "grossly excessive" and that Reynolds would appeal.
But Ms Robinson's lawyer Christopher Chestnut said the award sends a powerful message to tobacco companies that they "cannot continue to lie... about the addictiveness of and the deadly chemicals in their cigarettes".
The case is one of thousands filed in Florida after the state Supreme Court in 2006 threw out a $145 billion (£85.3bn) class action verdict.
Ms Robinson individually sued Reynolds in 2008.
Her husband Michael Johnson died in 1996.