While the Conservative leader has not faced any accusations of suffering from the Midas touch in recent weeks, the thought of a curse seemed excessive.
Could an endorsement from Downing Street really prove so damning?
Perhaps the public should beware if Number 10 ever starts sending out "Congratulations on your wedding" cards.
But the Prime Minister appeared to say the curse might affect something much more important than just matrimony. It might have an impact on football.
Responding to a question in the House of Commons, the Prime Minister said he wished Huddersfield Town Football Club well.
But then he went on to warn that his doing so may mean the club falls victim to the "Prime Minister's curse".
A shudder appeared to go through the backbenches of both parties.
"Memo to self", many MPs appeared to be thinking, "never ask him about my team".
But what does this bode for future encounters? Don't mention Euro 2012?
The irony was that the comment came after Labour leader Ed Miliband had tried his best to paint Mr Cameron as cursed.
His opening gambit was to ask what talks the Prime Minister has had with the new President of France, Francois Hollande, after he publicly backed his opponent Nicolas Sarkozy for the job. In response, the Prime Minister appeared to play the man, not the ball. The only problem was, it was the wrong man.
After a jibe from Mr Miliband, in which he said "I'm sure a text message and an LOL will go down very well," Mr Cameron replied that at least he knew how to use a phone and not just "throw them at people who work for me" – a joke that appeared to centre on allegations made against, er, Gordon Brown.
Still, at least no-one asked him about the England football team.