Scott Wilson, 46, from Biggar in South Lanarkshire, lost his gardening business and career as a reserve firefighter after developing Parkinson's.
He sold his house to the council and separated from his partner, who left home with his two children.
Mr Wilson stayed in his disability-adapted two-bedroom house under a mortgage-to-let scheme but has been told he has to move or have his housing benefit cut, Holyrood's Welfare Reform Committee heard.
The committee is taking evidence on the UK Government's under-occupancy charge, known as the bedroom tax. The policy cuts housing benefit by up to a quarter for those deemed to have additional bedrooms, but the committee heard of people having to borrow to meet moving costs, and abandon possessions and self-purchased fittings.
Mr Wilson said: "I recently separated from my partner, partly because of the stress that Parkinson's has put on my family life. I have lived in my home for 25 years.
"We had to sell it back to the council because of financial hardship."