The Tory MSP will warn that a Yes vote in the referendum could deny future generations the "life chances they deserve".
Ms Davidson will make a speech outlining the importance of staying in the UK to young Scots in Glasgow this morning.
During the address, she will insist that a vote to leave the UK would be "closing off avenues of opportunity for Scotland's young people that have existed for generations".
Ms Davidson will add that "we'd be selling young Scots short" if the ballot resulted in a vote for independence.
"Our young people are as dynamic and ambitious as their contemporaries in any other corner of the globe," she will argue. They've got what it takes to make it in life - the talent, the drive and the determination to make their mark on the world.
"It's our responsibility to make sure they get the best possible chance of achieving their full potential.
"So, when I vote on September 18, I'll cast my vote for No ... No to independence. But in doing so, I'll also be giving a resounding endorsement to Scotland staying in Britain."