The Labour leader will warn that politicians and business need to work together to cure underlying problems in the economy.
The call comes amid growing pressure over his party's stance the issue.
Yesterday two former senior Labour policy advisers, Lord Liddle and Patrick Diamond, warned the party would lose next year's general election if it is seen as anti-business.
But one apparent critic of Mr Miliband, Maurice Glasman, made a peer by the Labour leader, seemed to do a U-turn, saying "what is needed is a sense of direction and I think we've got it".
One shadow minister also cautioned colleagues against losing their nerve, saying "now is not the time to have a crisis of confidence".
Mr Miliband used his 2011 Labour party conference speech to warn against what he described as "predator" businesses.
Last year he announced a price freeze on energy bills if his party wins in 2015, prompting howls from the industry as well as delight from the public.
In a speech to a conference on inclusive prosperity today, Mr Miliband will say that deep-rooted problems in the economy, which began long before the 2008 financial crash, will remain a threat even during good years unless there is substantial reform.
Aides pointed to low pay as the type of issue that would linger even under economic growth.
Mr Miliband will declare that Labour and businesses have a "shared mission" to create wealth, jobs and profits. "Unless we change the way we do things, we simply won't create the high paying, high skilled jobs needed to improve the condition of our country and the rewards of growth will be unfairly shared," he will say.
"Labour will build a prosperity in which all can share. "And, in so doing, we can rebuild faith in business and in politics in Britain."