A superb century from Jean Symes had guided the Saltires to 258-4 at the Emirates Durham ICG. However, the South African's effort was undermined by a lack of discipline with the ball.
He was also ultimately upstaged by Mark Stoneman, who stroked a brilliant 136 not out as the county cruised to an eight-wicket win.
Hopes had been high that the Saltires highest 40-over total for almost two years would be converted into a second victory of the campaign. Instead, the Scottish bowlers, perhaps unnerved by the aggression of the Durham openers, completely failed to settle into any sort of rhythm.
A series of wayward deliveries were seized upon by Mark Stoneman and Phil Mustard who scored at almost eight runs an over to quickly claim the initiative.
Ali Evans and Matty Parker shared the punishment but even the introduction of skipper Gordon Drummond and Josh Davey brought no respite, the pair being greeted into the attack with a boundary. Even the normally parsimonious Majid Haq saw his first over bludgeoned for 12 runs as the relentless assault continued.
Stoneman was first to reach his half-century from 47 balls while Mustard followed soon after, needing only 40 deliveries.
There was even the rarity of a dropped catch by Preston Mommsen and a misfield by Richie Berrington to compound the misery.
Stoneman went on to record a blistering century from only 87 balls and went on to upstage Symes with a stunning century.
Mustard fell nine runs short of three figures, caught at mid-on by Evans off Parker. However, the county openers had put on 207 in 27 overs and victory was already assured. The end came all-too quickly, the county losing a further wicket when Ben Stokes fell to Haq but reaching their target with more than six overs to spare.
It was in stark contrast to earlier events as the Saltires batsmen recovered from last week's disappointing display against Hampshire.
Symes may have had his doubters among Saltires supporters when he recorded a duck on his debut against Surrey earlier in the month. But he proved himself a class act with a beautifully timed innings of power and skill.
The tone for a successful batting display from the Scots was set when Jamie Harrison over-stepped with the first delivery of the game and Davey dispatched the free hit over the short mid-wicket boundary. Davey and Calum MacLeod posted 33 for the first wicket in the space of some hostile bowling from Graham Onions.
The former England pace bowler made the breakthrough when a leading edge from Davey lobbed up to Stoneman at cover.
Symes, circumspect initially, and MacLeod set about rebuilding the innings before gradullay moving through the gears in a stand of 86 in 14 overs.
MacLeod led the way by whipping a couple of ferocious drives to the cover boundary while Symes just cleared Mitchell Claydon at deep square leg for the first of his three 6s.
MacLeod, looking set for his second half-century of the campaign, fell two runs short when he chased one from Claydon and edged to Mustard. However, the platform had been set and Symes, with the help of Berrington and Mommsen, took full advantage. Berrington's run-a-ball 29 included four boundaries while Mommsen's unbeaten 31 came at the same rapid rate.
However, centre stage belonged to Symes who, having survived a chance on 43, reached 50 came from 62 deliveries but needed just 29 more balls to post his century. The landmark included nine boundaries and two 6s and, by the time he was bowled by Plunkett from the final delivery of the innings, the powerful left-hander had sent one further maximum soaring into the pavilion.
Sadly, it was all in vain.
Gordon Drummond, the captain, admitted his side contributed to their own downfall. "It was a tale of two halves and we obviously thought we were in with a chance after posting a decent total."