Grant Elliott and BJ Watling both hit centuries for the Black Caps side, who were formerly under the charge of Scotland head coach Grant Bradburn, to give the home side a mountain to climb in Ayr.
The visitors posted a total of 347 for six before the Scots were bowled out for 148 in the 33rd over.
Scotland, with George Munsey making his debut, began relatively well as David Murphy caught Anton Devcich for 17 off the bowling of Alasdair Evans.
But wickets were subsequently slow to fall, and a second wicket for Evans and two for Majid Haq proved insufficient to stop New Zealand's second string racking up a significant total.
Scotland never looked like making serious inroads on the total from the moment opener Hamish Gardiner was trapped in front for four.
Munsey got off the mark with a four but his total of 16 was not enough to turn the tide and Richie Berrington top-scored with 42 as Scotland stuttered to a disappointing loss.