As the elements yet again badly affected the fixture list, the Glasgow outfit took full advantage of their opponents' fragile middle order batting.
The visitors must have fancied their chances when they restricted Clydesdale to 195 all out, skipper Zeeshan Bashir and Safyaan Sharif each hitting 44, but could only manage a miserable 129 in reply.
Renfrew clinched a surprise place in the knock-out stages by hammering Fauldhouse on home turf. Veteran Imran Adrees took six for 29 as the visitors were skittled for just 72.
The hosts cruised to victory for the loss of only one wicket. Ahmed Said was unbeaten on 38 and Mohammed Ramzan 26no.
Heriot's earned a ticket to the next phase by disposing of Ferguslie at Meikleriggs, but even the presence of former superstar pro Gordon Greenidge couldn't turn Greenock's fortunes at Glenpark.
The West Indian legend watched the fallen giants being demolished by Falkland. David Gray (84) and Nick Lockyer (75) combined to take the Fifers' to an impressive 254.
Greg McDougall was the pick of the home attack with five for 36. Brock Ditchman then bagged six for 21 from eight overs as he sent Greenock hurtling to 116 all out.
Dave McNulty made full use of the seam-friendly conditions at Hamilton Crescent to propel West of Scotland to an easy seven-wicket success against Stoneywood-Dyce.
The Aberdonians never got into their stride because of McNulty's accuracy and he finished with four for 24 as they tumbled to 84 all out after 29 overs. West reached the target in the 20th over with Ian Young contributing a watchful 29 not out.