Stuart McCall will ring the changes for the return fixture with Hamilton as Motherwell attempt to put their ongoing cup woes behind them by climbing up the SPFL Premiership table.
Motherwell failed to get over the first hurdle in a cup for the eighth time in nine attempts on Tuesday when they lost a League Cup penalty shoot-out at New Douglas Park.
The Fir Park side have only won one out of 15 knockout games but manager McCall has simultaneously led his team to consecutive second-place finishes in the league, and the focus will be all about points in the next Lanarkshire derby.
McCall said: "We will make a lot of changes for Saturday, there's no doubt about that. There were a lot of people running on empty and a few were carrying injuries late on.
"We will reassess it, but one thing we can't do is start feeling sorry for ourselves. We have got to start climbing the league and getting points on board.
"We will be up against a rejuvenated Hamilton again and they have proved why they are up there. They are very hard to break down, well-disciplined and well-marshalled, and on that [synthetic] surface we find it hard to create and score goals. But we are at Fir Park and we have to make sure we are ready."
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