A victory tonight will leave Wilmots' side within touching distance of the finals in Brazil with two games to go and a three-point advantage over Croatia at the top of Group A.
While his side remain unbeaten Wilmots is still expecting a stern examination of those credentials by a rejuvenated Scotland this evening and knows that a win is vital with a virtual group decider scheduled for the start of next month against the Croats.
The 44-year-old is under no illusions about the task in hand. The Scots succumbed to a 2-0 defeat in Brussels the last time the two side met in a match which proved to be Craig Levein's last in charge but have since steadied the ship with the appointment of Gordon Strachan, recording a 1-0 win over the Croats in Zagreb and impressing in the defeat by England at Wembley last month.
"We will suffer tomorrow, that's for sure," said the former Standard Liege and Schalke 04 midfielder. "Scotland are not that bad because they played two very good games against very good opponents, Croatia and England.
"They had a bad start to the group but now they are back. They are in a winning spirit, in a good spirit. They are playing at home. They are already eliminated and they can play more relaxed, more free. They have a new coach and they had a great result against Croatia and a good game against England, where they were leading twice.
Wilmots is waiting on the fitness of four key players, with Jan Vertonghen, Eden Hazard, Nacer Chadli and Axel Witsel all injury doubts.
"We will see tomorrow who is fit and who is not and we will make the decision we have to make. We will do everything to win tomorrow with no fear. Everyone who plays will be ready and focused on the game."
Like Wilmots, Vertonghen fully expects Scotland to be a different proposition to the side they met last October.
"It will be a very hard game for us. We played them at home and they were very difficult to beat," said the Tottenham defender. "At Hampden, it will be even more difficult. We will have to be at the top of our game. They did well against Croatia and England.
"I think we will see another Scotland tomorrow. They looked very confident in their last two games. Everybody has to be at 100% to beat Scotland at Hampden."