The problem, which stems from bone damage, has been troubling the Dutchman for much of the season.
It has become a greater pain this week, though, since Boerrigter has acknowledged that he will not be fit enough to feature against the club he left in the summer. He will be joined on the sidelines by suspended captain Scott Brown and injured full-back Adam Matthews, while the fitness of defender Mikael Lustig will also be assessed.
"There is bone damage and I have calculated that I will need to miss the match against Ajax," said Boerrigter. "I would have liked to play in the match because it is an enormous game for both clubs now."