The American company replaces German sportsware manufacturer Puma and will supply all Hibs' first-team strips as well as training gear until 2017.
The new contract will begin with the unveiling of the team's new home kit on Friday, June 7.
Hibs chairman Rod Petrie said: "The run-up to a change of technical partner is always a demanding time for the club. Puma has served us well for four seasons, for which we thank them.
"Everyone at the club is excited about securing the number one global sportswear brand as our new technical partner for the next four years.
"Nike is synonymous with sporting excellence and has a rich heritage in providing the highest quality of products throughout professional sport.
"We have worked very closely with Nike on the designs for next season and I am sure the new kits, merchandise and the new look Hibernian Nike Cubstore will be well received by our supporters."
Simon Taylor of Nike added: "Nike are delighted to have signed a deal with Hibernian and look forward to supplying the club and its supporters with an exciting range of kits, training and leisurewear over the next four seasons.
"Hibernian are a club with a great tradition in Scottish football and it is a pleasure to welcome them into the Nike family in what will hopefully be a long and successful partnership."