Here are the key battles:
GEORGIOS SAMARAS v STEFANO DENSWIL
Samaras has been on impressive form on the European stage in recent years, but has not found the back of the net in Continental competition since the qualifiers against Cliftonville.
The Greek striker will be hoping to rediscover the form that saw him net a hat-trick against Kilmarnock last month - the last time he hit the target.
Aiming to stop the Hoops forward - and help Ajax claim their first clean sheet of the group stage - will be defender Denswil. As well as shoring up the rearguard, he is also the only player to score for the Dutch outfit in the Champions League proper this term.
CHARLIE MULGREW v SIEM DE JONG
With Emilio Izaguirre expected to return from illness to reclaim his place at left-back, Mulgrew is likely to be moved back into the middle of the park.
The absence of suspended skipper Scott Brown will mean more onus on Mulgrew in the midfield battle. He is set to come up against Ajax captain De Jong who, at the grand old age of 24, was the oldest player in their side at the weekend and is set to provide the experience in what will be a young team.
VIRGIL VAN DIJK v KOLBEINN SIGTHORSSON
With Holland boss Louis van Gaal reported to be taking in the clash at Parkhead, Van Dijk could not ask for a better chance to impress and boost his international hopes.
As a Dutchman, he will also boast in-depth knowledge of the opposition.
Sigthorsson was linked with a move to the Hoops last month and it is easy to see why. He netted the leveller against FC Twente on Saturday and was also on target for Iceland in their World Cup qualifiers against Cyprus and Norway to bring his tally to 10 goals this season.