Poyet, the former Brighton and Hove Albion coach, will inherit a club left stranded at the bottom of the Barclays Premier League with just one point from their first seven games and six points adrift of safety.
"The time of Paolo has come to an end and it is time to move forward," said Poyet. "We are all different and I don't think it is right to compare people. I know a lot about the players at Sunderland, and I know for them it is going to be even more difficult now with another new manager."
He also revealed that Kevin Ball, the assistant manager who has been in charge of the team since Di Canio left, will have a major part to play in the new regime. "He doesn't know yet how important he is going to be for me," Poyet admitted. "I am going to count on him a lot."