Forfar Athletic v Brechin City (7.45)
Forfar have selection problems to overcome if they are to harbour hopes of booking their place against St Johnstone in the fifth round.
Stuart Malcolm and Mark Baxter are both banned after being dismissed during the first meeting and manager Dick Campbell has injury worries as well. Dale Hilson is already out with a hamstring problem and Iain Campbell, Martyn Fotheringham, scorer of the equaliser in the 1-1 draw, Omar Kader and Gavin Swankie are all doubts after Saturday's game with Dunfermline.
"I will start looking to name a team on Tuesday afternoon once I have a yes or no answer on the injured players," said Campbell. "The team may just pick itself due to a shortage of bodies."
Campbell cannot call on the Aberdeen loanee Craig Storie, who is unavailable for cup matches.
Ray McKinnon, the Brechin manager, says the prospect of bringing St Johnstone to Glebe Park will be incentive enough for his players.
"To play a Premiership side at home is a very attractive proposition and one that would be really exciting. Hopefully the prospect of that will give our players that little bit of something extra that may be required to see off Forfar as there is very little between the sides."
Ewan Moyes and Stuart Anderson are suspended with winger Bobby Barr also missing out after groin surgery.
Stranraer v Clyde (7.45)
Stranraer manager Stephen Aitken's reputation grew throughout November as his side knocked Auchinleck Talbot out of the Scottish Cup and then registered wins over Ayr United, East Fife and Airdrie. It earned him a second successive SPFL League 2 Manager of the Month award.
For Aitken, the only disappointment was the first-half display at Clyde when the teams first met. "We were poor at the start of that game and Clyde could have been out of sight. They played well but thankfully they only scored the one goal. We got back into things just before the break and were better in the second half but Clyde more than deserved their draw. The one good thing is that we now know how good they can be and therefore we have to be up for it from the first whistle. We are now at the stage where we are favourites for games and we have to show that we can keep handling that."
Striker Martin Grehan returns after a ban, but on-loan Aberdeen player Scott Rumsby will be unavailable and Mark Corcoran is ruled out with a hip problem.
Jim Duffy believes Clyde are still in with a real chance of booking a tie against Inverness Caledonian Thistle. "We played really well in the first meeting and showed what a good side we can be. With a bit better finishing we could have had a commanding lead after just half an hour. We can take confidence from that first game because the players know that they can trouble Stranraer."
The manager knows his men will have to lift their game after being replaced at the top of League 2 by Peterhead, who beat them 3-1 at the weekend. "We were well off the pace on Saturday and it was a disappointing game. I am looking for us to bounce back and show what we are capable of at Stranraer."
Goalkeeper Jamie Barclay is not yet ready to return after an ankle injury and former Stranraer forward Stuart McColm is a major doubt after picking up a hamstring injury.