The Jamaican has won triple gold at the last two Olympics in the 100 metres, 200m and sprint relay.
But the 26-year-old, who is also world champion over 200m and who will attempt to regain the 100m title from training partner Yohan Blake in Moscow next summer, has never won a Commonwealth medal. He missed the 2006 Games in Melbourne through injury and decided not to compete in Delhi to concentrate on his preparations for the London Olympics.
"That's the only title I don't have so I think it's something I'd like to go for, even if I do just one event," Bolt said, speaking in Barcelona where he was named male athlete of the year by the International Association of Athletics Federations (IAAF).
Bolt also confirmed he will continue to concentrate on the 100m and 200m next year. He added: "We've decided with my coach that we're not going to do the 400 or the long jump so it's going to be the 100 and 200. It's all about trying to go as fast as possible. Try to stay injury-free, make sure I do my back exercises so I'm strong and I'm ready."