The giant 26-year-old from Inverness features as the main support on a Frank Warren charity bill at the Hilton Hotel, against Czech Jiri Svacina.
No Scot has ever contested the heavyweight version of the Lonsdale Belt, but Cornish's manager, Tommy Gilmour believes his boxer is capable of making history. "This is a high profile fight for Gary as much as anything," he said. "It is further exposure for him in the capital and his bout is also being televised on BoxNation.
"If he performs well, a fight like this on nationwide TV can open more doors for Gary and that's important at this stage of his career. Svacina went the distance with Sam Sexton in his last fight so he'll provide Gary with a decent test of where he's at."
The 36-year-old Svacina has a patchy 12/10 record, and Cornish is coming off the back of a British Masters title stoppage against Paul Butlin in Inverness in July.
Gilmour also confirmed plans are in the pipeline for Cornish to fight twice more before the turn of the year, hopefully on television.