The 31-year-old, who is gearing up for a 5000 and 10,000 metres double at the European Championships in Zurich next week after pulling out of the Commonwealth Games following illness, will take on Stephen Kiprotich, the reigning world and Olympic marathon champion, on Tyneside.
It will be Farah's second attempt to win the Great North Run after he was beaten to victory in a thrilling race last year by Kenenisa Bekele, with Haile Gebrselassie trailing in third.
Farah had intended to run three times at Hampden Park this summer, a two-mile event at the Glasgow Diamond League Grand Prix followed by the 5000/10,000 double at the Commonwealth Games.
He withdrew from the Grand Prix before becoming embroiled in an on-off saga over his participation in the Games. He said yesterday: "I'm looking forward to returning to the North East to run my second Bupa Great North Run. I have been part of the weekend several times in the past.
"Last year was a great race with Kenenisa and Haile over the half marathon. I would like to come back and win this year."
The race would be Farah's first on the road since he finished eighth in the London Marathon in April.