Sir Henry Cecil's superstar is bidding to sign off with win No.14 in a Group 1 race that Cecil has claimed twice in the past three years with Twice Over.
Cirrus Des Aigles struck in this race 12 months ago and the French challenger will return to England to defend his title.
With the John Gosden-trained Nathaniel also preparing to take his chance, Frankel is likely to face the stiffest test of his career.
Although his major challengers are perhaps more at home on the soft ground, connections of the favourite are unfazed by the prospect of testing conditions.
"I don't think the ground is a worry," said Teddy Grimthorpe, racing manager for owner Khalid Abdullah.
"He's encountered good-to-soft and good-to-firm and handled that well – I wouldn't think soft would be that much of a problem."
* Jim Goldie maintained his stranglehold on the Willie Park Trophy when 7-1 shot Gordonsville yesterday landed Musselburgh's two-mile feature for the second time in three years.
The Renfrewshire trainer, who also had the first three in the corresponding race 12 months ago, saw his veteran beat Come Here Yew by a neck, with stablemate Jonny Delta two lengths back in third place.
Goldie said: "He had a bit too much use made of him last time at Newmarket but he was a really good second at Thirsk the time before. This is a career-best effort in his ripe-old and he's an old superstar. He's entered at the sales at Doncaster shortly but I'm not sure if he'll go now."
The other main event of Scotland's final Flat card of the year, the Batleys Scotland Handicap, went to 18-1 chance Kingscroft, ridden by Joe Fanning.
Linda Perratt's hot streak continued when she saddled her fourth winner in a fortnight, courtesy of 40-1 outsider Weetentherty in the M&F Funeral Services Handicap.
William Haggas took his course strike rate to 33% after Leitrim Pass, also owned by the Newmarket trainer, landed the British Stallion Studs Supporting British Racing with Phillip Makin doing the steering on the 10-11 favourite.
*Richard Hughes left bookies running for cover at Windsor yesterday after nailing a remarkable 10,168-1 seven-timer on the eight-race card.
Pivotal Movement (13-8 jt fav), East Texas Red (5-2 fav), Embankment (7-1), Magic Street (4-1 fav), Links Drive Lady (5-2 fav), Duke Of Clarence (7-4 fav) and Mama Quilla (15-8) were the horses who obliged for the champion jockey-elect.
Contextual targeting label: