She finished ahead of Denmark's Julie Aglund Lauidsen and Plymouth Leander's Shauna Lee to underline her good form ahead of next month's Commonwealth Games in Glasgow.
But the spotlight fell on Ben Proud who secured a hat-trick of gold medals. And the 19-year-old hopes his winning streak also continues at the Commonwealth Games.
The Plymouth Leander swimmer came home first to add the 100 metre freestyle medal to his tally as he finished just outside the 49.41seconds personal best he set in the heats, taking gold in 49.78secs.
City of Manchester's Daniel Briggs recorded the second fastest time in 50.74 and Calum Jarvis of British Gas NTC Bath claimed bronze in 50.81.
Proud, who last week claimed the 50m freestyle and 50m butterfly titles, said: "I thought I'd go out as fast as I can. It worked and I set a PB.
"This morning was probably the fastest morning swim I've done so I'm feeling confident. I'd like to hope I can swim a 48. It's what I'm working towards."
British champion Rachael Kelly came home in 58.76 to take her second gold of the meet in the 100m butterfly.
The British Gas NTC Loughborough swimmer was pleased with her time, despite just missing her PB, and said: "Winning my first British title in Glasgow earlier this year gave me a lot of confidence. I wasn't sure what to expect coming into this meet so I'm pleased to have raced close to my PB."
Her Loughborough team-mate, Roberto Pavoni, struck gold in the 200m individual medley, while Chris Walker-Hebborn, swimming for Ellesmere College, won the 50m backstroke title.
City of Liverpool's Georgina Evans claimed the 50m breaststroke title in 32.58 and, in the 200m backstroke, a time of 2:10.43 handed British champion Lauren Quigley of Stockport Metro the gold medal.