Red Bull team principal Christian Horner described Vettel's drive en route to taking the chequered flag at the Italian Grand Prix for the third time as "flawless".
That was with a small exception of a lock-up into the first chicane on the opening lap when he flat-spotted his front-right tyre.
Aside from what was a rare error, Vettel coasted to another easy win, as was the case a fortnight ago in Belgium, for his sixth victory in 12 races this season and 32nd overall of his career.
It was no surprise, therefore, when he stepped on to the podium and ahead of being interviewed by the only man to win world titles on two and four wheels, John Surtees, the Ferrari fans rounded on Vettel.
It is the third time this season -Canada and Britain were the other two events - where Vettel has been jeered, suggesting his popularity is waning, the hallmark of a repetitive winner.
Taking it all in his stride, the 26-year-old German said: "You can hear the difference when you don't win in a red [race] suit.
"You get a lot of that, but it's very nice because it means you've done a very good job and beaten the red guys, so we are very proud of that."
Horner believes Vettel will only be fuelled by the booing as he said: "Anybody racing and beating a Ferrari at Monza is never going to be cheered."
As for Vettel's rivals, Fernando Alonso provided Ferrari fans with some cheer as he finished second, but has fallen 53 points adrift in the title race.
On the back of a disappointing display in qualifying for both Kimi Raikkonen and Lewis Hamilton, their situation failed to improve in the race. Hamilton collected a slow puncture at the first corner as a result of Raikkonen running into the back of McLaren's Sergio Perez. In a one-stop race, Raikkonen was forced to pit immediately for a new front wing, whilst Hamilton required fresh rubber after 13 laps once his problem became apparent.
Both produced charges through the field, but in needing a second stop, Hamilton could only finish ninth and Raikkonen 11th to leave them 81 and 88 points behind Vettel.
Vettel and Alonso were joined on the podium by Mark Webber, with Ferrari's Felipe Massa fourth ahead of Sauber's Nico Hulkenberg.
McLaren's Jenson Button was 10th and Max Chilton 19th for Marussia, whilst Paul Di Resta crashed out at the first corner in his Force India after running into Lotus' Romain Grosjean, earning a reprimand from the stewards.
After crashing into a barrier in final practice on Saturday morning due to a brake failure, Di Resta's race lasted a matter of seconds. Starting from 15th, and with nowhere to go as the field bunched in front of him approaching the first chicane, he collided with Grosjean, breaking his left-front wheel.
Summoned to see the stewards post-race to explain the incident, the Scot was handed a reprimand when it could easily have been a grid penalty for the next race in Singapore.
Suggesting he was fortunate not be hit hard by the stewards, Di Resta said: "In a sense, but I didn't damage Romain's car. It was one of those things. He came into the [stewards'] meeting and said I never damaged it.
"It has been one of those weekends to forget."