With a 46-point lead over his nearest rival - Ferrari's Fernando Alonso - going into Sunday's Italian Grand Prix, Vettel is determined to cement his place in F1 history.
Alonso, along with Lewis Hamilton and Kimi Raikkonen who are 58 and 63 points adrift respectively, desperately require Vettel to slip up or suffer some sort of mechanical failure.
The 26-year-old German, however, showed no sign of relinquishing his vice-like grip on his championship lead after the opening practice sessions around one of F1's most revered of venues, Monza.
Vettel clocked a lap of one minute 24.453secs, finishing comfortably ahead of the field.
Vettel, however, knows he cannot afford to get carried away with how the title fight is shaping up.
"Our focus should be on every single race and not be distracted by what is going on around us," he said.
"I try not to look at one particular guy or two particular guys. I try to look after myself and to achieve my maximum. If I do that, I have the best chance to win the championship.
"I am trying not to look at the difference in the points. I am trying not to get distracted."
Vettel added: "There are a lot of races to go, a lot of points to score. You don't have to be a genius to work out there are more points to score (200) than we currently have (197).
"So that is the approach. Anything else would be wrong."
Hamilton, on a run of four consecutive pole positions, with Vettel joining him on the front row at the last three, believes there is more Mercedes can do to propel him forward.
Quickest in first practice on the hard compound tyre, Hamilton was only sixth-fastest on the medium Pirelli rubber.
But Mercedes and Hamilton have made a habit recently of coming good on Saturday after suggesting on Friday they are off the pace.
"Hopefully we can improve the pace," said Hamilton. "We're not as fast as the Red Bulls. They are quick, but we are still confident because the car generally feels good."