Feeling wounded after an opening championship 18-6 defeat to France last week Gary Street's side overcame a heavy pitch and a buoyant Scotland side to command this win.
The victory now sets England up for a significant clash against reigning Grand Slam champions Ireland at Twickenham on February 22.
England opened their account early on with Joanne McGilchrist returning from injury to score after just six minutes. Amber Reed, Lydia Thompson, Claire Purdy and Sarah Hunter all then went on to score in the first half.
Skipper Katy McLean led by example after the restart with a 49th-minute try. Hannah Gallagher made a good break after Scotland were penalised before Purdy and then Mclean showed strength to barge her way over the try-line.
England tested Scotland further when they made a whole host of substitutions and it showed in some powerful scrums and drives which the hosts could not handle. The results came with Emily Scarratt and Maggie Alphonsi both scoring from some good work by the forwards.
Claire Allan, Sophie Hemming and Gallagher then rounded off proceedings as Scotland no longer could cope with this much-improved England side.