Deborah McCormack, a second-row with Richmond, is the only one of the four to feature in the starting XV but on the bench are the Murrayfield Wanderers duo Lisa Robertson and Emma Wassel, as well as Anna Stodter of Loughborough University.
The squad will still have an core of experience, with old heads Lindsay Wheeler, Heather Lockhart and Louise Dalgliesh - all of them have broken the 60 cap mark - named in the travelling 23, though Lockhart and Dalgleish will be on the bench.
Maxton, said: "The uncapped players named are those we see as having great potential for the future, with one of the aims for this season being to provide opportunities for new players moving forward over the next few seasons. It's about the balance of having experience, and developing and rebuilding our team.
"We've got the return of Ruth Slaven, Lisa Martin and Gillian Inglis, all whom have a great deal of experience and are very important. This is a new team and this weekend we want to set the standard. We can't just say we want to win, we have to look at how we achieve that."
TEAM. Scotland Women (v Ireland, Ashbourne RFC, near Dublin, Friday, 7.30)
S Johnston (Worcester); K Green (Darlington Mowden Park), A Sergeant (Richmond), G Inglis (Melrose), M Gaffney (Hillhead-Jordanhill); L Martin (Murrayfield Wndrs), S Law (Murrayfield Wndrs); T Balmer (Worcester, capt), S Quick (Murrayfield Wndrs), L Smith (Hillhead-Jordanhill), J Konkel (Hillhead-Jordanhill), D McCormack (Richmond), T Forsberg (Richmond), R Slaven (Murrayfield Wndrs), L Wheeler (Saracens). Substitutes N McLeod (Stirling County), L Robertson (Murrayfield Wndrs), H Lockhart (Hillhead-Jordanhill), E Wassel (Murrayfield Wndrs), A Stodter (Loughborough Uni), L Dalgliesh (RHC Cougars), T Griffiths (RHC Cougars), L Steven (Murrayfield Wndrs)