The British and Irish Lion went off injured in the first half of Scotland's RBS 6 Nations defeat by Ireland in Dublin on Sunday.
Paul McGinley, the Scottish Rugby Union's head of medical performance, said: "Sean suffered a concussion as well as injury to his right leg [on Sunday]. He will be subject to further investigation [yesterday] at Spire Murrayfield hospital and will be assessed later by consultant surgeon Graham Lawson. We also have a number of injuries at this juncture which will [have an] impact on availability to train at the start of this week but we are optimistic that players will recover in time for the England game."
Maitland's absence is likely to open the way for Dougie Fife, the Edinburgh player who has caught the eye this season, to earn his first cap, most likely from the bench.