Jenkins and company will head to English rugby headquarters in pursuit of a fourth successive victory over their fiercest rivals. It would also extend their hopes of achieving an unprecedented Six Nations title hat-trick into the tournament's final weekend when they host Scotland.
Resurgent England, though, will clinch a first Triple Crown since 2003 by avenging last season's record 30-3 drubbing in Cardiff and with their final game on Saturday against Italy in Rome, edge closer towards potentially ending an 11-year title wait.
It will be triple Grand Slam winner Jenkins' 10th Six Nations appearance against England - he has been on the losing side just three times - on a day that sees him equal Stephen Jones' Wales record of 104 Test-match appearances.
"There is no bigger challenge than playing at Twickenham," said Jenkins. "I've been lucky enough to get one or two wins there, but it is a fortress for them and a tough place to get a win, especially with the way England have been performing over the last year or two and the way they have progressed.
"They are a young and fit team. They seem to have a very good work ethos and they play for each other. We know we have a tough battle on our hands. Everything is on the line on Sunday. It's pretty much whoever wins has a chance of getting the championship. If you lose, you are out of it."
Wales recovered from a Dublin no-show against Ireland four weeks ago by crushing France 27-6 last time out, and that impressive recovery act kick-started momentum that could yet lead to a fourth Six Nations crown of Warren Gatland's coaching reign.
"We knew that Ireland wasn't acceptable," Jenkins said. "We were beaten in a lot of different areas. We accepted that training wasn't as good as it could have been during that week and the standards weren't where we wanted them to be.
"I suppose we just wanted to prove to ourselves and to the coaches what we could do against France. We wanted to turn up on that Friday and put the Ireland game out of the memory.
"Luckily, we did that. In the build-up to the France game we went back to what we are strongest at, with sharp training sessions and fine detail which we may have let get away from us against Ireland."
Yesterday, Wales received a warning from England No 8 Ben Morgan that should they be planning to target him it will be at their peril.
Two years ago it was revealed that Wales had zeroed in on Morgan just three caps into his Test career and the bulldozing Gloucester forward is happy should that policy continue.
"It's a compliment if people start targeting you because it means you are doing something right, so I'm pleased if I was targeted," he said. "I don't feel that sort of pressure - when you break rugby down it's a simple game, particularly in my sort of role. I try to get the team over the gain line and if I can do that then great.
"If people are trying to make it harder for me by putting two or three people to tackle me, the spaces are going to open up for the rest of my team to attack elsewhere. It's nothing that worries me. If anybody focuses on one or two players they miss the rest of the team."
Morgan has braced England for the usual power-based game from Wales - more commonly known as 'Warrenball' after Gatland - and insists their route one approach must be met head on.
"Wales have a handful of players they use to get over the gain line," he said. "They use the likes of Jamie Roberts, Richard Hibbard and Toby Faletau. They are all big men and that is the way they like play.
"If you look at their team from one to 15 they are all big men and all about getting over the gain line. We can't let them do that because that is when they start to hurt you."