The Wimbledon champion has been given a wildcard for the event, which is also set to feature Juan Martin Del Potro - the defending champion - and Tomas Berdych.
The Scot's entry suggests his back remains in a good condition following his return from surgery and a gruelling schedule over the last month consisting of the Australian Open and the Davis Cup.
Murray is scheduled to play in Acapulco later this month before the higher-profile tournaments of Indian Wells and Miami.
"Last week I contacted Andy Murray and his management," said Rotterdam tournament director Richard Krajicek.
"Because he didn't have a tournament planned between Australian Open and Acapulco and came back from Australia free from physical issues, it seemed like a good idea to both of us if he came to Rotterdam.
"After consultation with his coach Ivan Lendl he decided. Obviously this is a great addition to our already very strong field. An excellent opportunity."