On Friday it was the Argentine Leonardo who, eventually and emphatically, was put to the sword. Yesterday, his German namesake Florian stood in the way of the Scot making the last 32 of the US Open he is attempting to defend for the first time.
While both Mayers caused problems with their contrasting styles, the result was both ultimately the same and never in doubt.
Murray struggled with the sapping humidity in the first set; it was horribly sticky, the sun struggling to peek through a muggy sky. The world No.3 looked sluggish, his body language downbeat - in these tough conditions, it was understandable. When it mattered, though, when he really had to step up and show the class which has elevated him to the status of one of the best players on the planet, Murray duly obliged.
The challenge of a first set tie-break was overcome with ease, allowing the Scot to build a platform which saw him motor brilliantly through the gears in the remaining two sets to free-wheel into the second week.
Mayer came into the match in decent form, having not lost a set in his opening two matches against Juan Monaco and Donald Young, but that unblemished record was never going to last, even if Murray did struggle to get out of the blocks.
This contest started closer than the final score suggested. Mayer certainly offered a different challenge for the Scot, his tall frame conducive to his hard-to-read, laconic, slightly unorthodox style.
The opening exchanges were unremarkable, Murray failing to take two break points in the German's first service game before a routine hold put him on the board. The uncomfortable conditions had the reigning champion perspiring from the off; the tetchy nature of his start was illustrated by a look and moan towards his box at the end of the third game.
He seemed at odds with himself. A bit like the bad, old days when he growled and scowled on court with what seemed like the weight of the world on his shoulders. But he remained unbroken as the scoreboard reached 4-4, even if he had managed to get in just 32% of his first serves.
Mayer wasn't consistent enough to capitalize but his unorthodox style was still hard for Murray to break down; the German came to the net 17 times in the opening 10 games compared to just twice for Murray.
The inevitable tie-break was upon us and in a flash Murray was 4-0 up. It was Mayer who was suddenly ragged and a driven backhand down the line ensured his mood darkened even more as the first set went the way of the Wimbledon champion. Murray had a chance to regroup and he kept the pressure firmly on.
In the first game of the second set, two superb driven returns built the platform for the first break of the match. The second almost came instantly but Murray managed to save a break point before doubling his lead. His serve was better and Mayer was struggling to stay afloat.
The Scot had upped his level considerably and soon enough he was two sets to the good. Mayer could not live with Murray's movement; he continued to keep the German at bay and a flicked lob helped set up a break point which was gleefully accepted and saw his opponent go 3-1 down and far too deep in trouble.
Murray will now face Denis Istomin in the third round, but Mayer will be leaving New York along with Britain's Dan Evans. The 23-year-old, though, will leave happier with his performance.
The British No.3 has also been given the full backing of Murray, who has been mightily impressed watching him progress with new found maturity, believing perhaps that this gifted-yet-unpredictable likely lad can fulfil his full potential.
Evans came agonizingly close to pulling off another major US Open shock, losing to Tommy Robredo 7-6, 6-1, 4-6, 7-5 to miss out on the chance of a fourth-round date with Roger Federer. Looking down and out after the opening two sets, the world No.179 displayed a fighting spirit and his impressive quality to pocket the third set and come within two points of forcing a fifth.
Nerves allowed the experienced Spaniard to come out on top in the end, but this run has been unquestionably the finest series of displays in Evans' career. Murray has always rated the 23-year-old - it was his wild party lifestyle which had apparently annoyed the hardworking Scot.
"I hear Andy was tweeting support for me during the match; he doesn't have to do that," enthused Evans. "I've definitely seen a change in his personality towards me. Especially after I came through the qualifiers.
"I think he is giving me more respect now. Someone can be saying to you, you should be doing this or that; he has always said that I am talented but I wasn't winning the matches.
"It's good now that he's seeing that I am applying myself and I'm doing what I need to be doing."