Ronald Koeman gained revenge on his old adversary Louis van Gaal as Southampton recorded their first win at Manchester United for 27 years.
A magical performance from Eden Hazard was not enough to inspire Chelsea to victory as Southampton held firm to secure a hard-earned point.
Sheffield United's match-winner Marc McNulty had to pinch himself after his goal earned victory over Southampton and a place in the Capital One Cup semi-final.
Robin van Persie's brace handed Manchester United a 2-1 victory at Southampton and gave Louis van Gaal first Premier League blood in his 10-year feud with Ronald Koeman.
Yaya Toure and Frank Lampard's strikes took Manchester City up to second in the Barclays Premier League table and handed Southampton an ominous start to a daunting run of festive fixtures coming up.