Patrick Bradley, 29, was found seriously injured at a house in Greenock in the Inverclyde area and later died in hospital.
Police believe three or four people were involved in a disturbance at the property on Wellington Street at around 1.15am.
A second man aged 37 was injured and taken to Inverclyde Royal Hospital where his condition was described as stable.
Police Scotland has asked anyone with information to come forward.
Detective Inspector Una Maider said: ''Wellington Street is residential and there is no doubt that people would have either seen or heard the disturbance take place."