Located in the Pinheiros District of São Paulo, the new bar will be the first opening of 2014, kicking off BrewDog's aim to open eight new UK and international bars this year.
BrewDog São Paulo has a capacity of 140 and features 15 beers on tap - including WayDog, a pale ale made by Brazilian brewery Way Beer especially for the bar.
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The bar will be open in time for the 2014 World Cup which will be hosted by Brazil.
Last year saw BrewDog open its first international bar in Stockholm, Sweden as well as a third London bar in Shepherd's Bush.
Not content with its apparent global domination, the brewery is also looking at potential bar locations in cities as far flung as Tokyo, Berlin, New Delhi and Brussels.
In another expansion, the brand will be opening a string of off-licenses in 2014 - starting with BottleDog King's Cross in London this spring.