Nicola Sturgeon will use a speech in Washington DC to slam the UK government's Brexit stance and argue for a second referendum.
She is also expected to make a case for a second Scottish independence referendum.
The First Minister will use her speech to highlight that Scotland's national interests are not being taken into account. She said: "In the independence referendum in 2014, voters in Scotland were repeatedly told that if we became independent, we would have to leave the European Union.
"Voting to stay in the UK was portrayed as the way to protect our EU membership.
READ MORE: Nicola Sturgeon: UK 'not remotely prepared' for Brexit
"That in itself raises the question of whether decisions about Scotland should continue to be taken at Westminster - or whether it would be better if they were taken in Scotland.
"And now the ongoing chaos at Westminster and the way Scotland's interests have been consistently ignored, makes that question even more relevant.
READ MORE: Marianne Taylor: The moral case for independence is clear, but it's a hard sell economically
"So I have said I will outline my thoughts on the timing of a possible independence referendum in the next few weeks - once the terms of Brexit are clearer.
"But, amid the chaos, confusion and uncertainty of Brexit, one thing is clearer than ever.
"Namely, that Scotland's vital national interests are not properly served by relying on the Westminster system which treats Scotland as an afterthought, and that those interests can only properly be served by being an independent country."
A UK Government spokeswoman said: "Nicola Sturgeon needs to stop using Brexit as an excuse to pursue her unwanted independence agenda.
"Rather than constantly seeking division and constitutional upheaval, she needs to work with the UK Government to avoid a damaging no-deal. That is what people and business in Scotland expect."
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