Cannabis plants with an estimated street value of around £1.4 million have been recovered.
Officers were called to Cheapside Street in Glasgow on Monday after an alert from a member of the public.
Acting under warrant, the officers searched a building and discovered more than 2,300 cannabis plants.
READ MORE: Police snared 'most sophisticated' organised crime gang in drugs raid
Inquiries are ongoing to establish how the cultivation - one of the biggest in the west of Scotland - came to be there.
Detective Inspector Davy Hill, of Greater Glasgow Proactive Unit, said: "We reacted to a call regarding this property and as a result discovered a large-scale cannabis cultivation site, one of the biggest in the west of Scotland.
"A substantial amount of cannabis plants will now be taken out of our community and will significantly impact those involved in drug dealing.
READ MORE: Drugs worth more than £50,000 found in Castlemilk during raid
"Criminal activity such as this will not be taken lightly and we will continue to carry out inquiries to find those responsible for this site, and anybody else linked to the growing and distribution of drugs.
"We encourage anyone with any information to come forward and contact us. You can be reassured that we will act on any information we receive."
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