A Covid-19 vaccine being developed at the University of Oxford was found to be safe and induce an immune reaction according to preliminary results of the study.

Researchers say their tests have revealed that the jab could provide double protection against Covid-19.

The early stage trial found that the vaccine is safe and causes few side effects.

READ MORE: Coronavirus: Oxford vaccine 'appears safe' and can train immune system

But what happens next?

More testing needs to be carried out to focus on the immune response measured in the laboratory, with further testing also needed to confirm whether the vaccine effectively protects against infection.

An ideal vaccine against Sars-CoV-2 should be effective after one or two vaccinations and work in target populations including older adults and those with other health conditions, researchers say.

They add that it should confer protection for a minimum of six months, and reduce onward transmission of the virus to contacts.

However, the experts warn that the current trial, published in The Lancet, is too preliminary to confirm whether the new vaccine meets these requirements.

Phase two – in the UK only – and phase three trials to confirm whether it effectively protects against the virus are taking place in the UK, Brazil and South Africa.

The trial included 1,077 healthy adults aged 18-55 years with no history of Covid-19, and took place in five UK hospitals between April 23 and May 21.

The data included in the paper covered the first 56 days of the trial and is ongoing.

The participants either received the new vaccine (543 people), or the meningitis vaccine (534 people).

Some of them – 56 given the vaccine, and 57 in the control group – were also asked to take paracetamol before and for 24 hours after their vaccination to help reduce vaccine-associated reactions.

All volunteers gave additional blood samples and underwent clinical assessments to determine if the vaccine was safe and whether it provoked an immune response.

The most commonly reported reactions were fatigue and headache, but some participants also reported pain at the injection site, muscle ache, malaise, chills, feeling feverish, and high temperature.

In addition, in the 10 people who received the extra dose of the Covid-19 vaccine, side effects were less common after the second dose.

The research found that the vaccine stimulates an antibody and T-cell response.

Antibodies are proteins produced by the blood in response to antigens, which are harmful substances that come from outside the body, such as from viruses or bacteria.

If the non-specific immune cells which respond to any invader instantly cannot tackle it, the T-cells come into play.

They take two forms – helper T-cells and killer T-cells.

The latter attack the virus directly.

T-cell responses targeting the Sars-CoV-2 spike protein were markedly increased in the 43 participants studied, peaking 14 days after vaccination.

This level declined slightly by day 56 of the trial.

Researchers also found that the T-cell response did not increase with a second dose of the vaccine.

Antibody responses in those given a single dose peaked by day 28, and remained high until the measurement at day 56 in the trial.

This response was boosted by a second dose.

Four weeks after vaccination, neutralising antibody responses against Sars-CoV-2 were detected in 32 of 35 participants, and in 35 of 35 participants – depending on the test – who received a single dose of the vaccine.

These responses were also present in all participants who had a booster dose of the vaccine.

The authors note a number of limitations to their study, saying more research is needed to confirm their findings in different groups of people – including older age groups, those with other health conditions, and in ethnically and geographically diverse populations.

In the current trial, 91% of participants were white and the average age of participants was 35 years.