Scotland is “firmly heading in the right direction” in the fight against coronavirus, Nicola Sturgeon has said.

The First Minister said the R number, the average rate at which a person with Covid-19 infects others, is estimated to remain below one.

Scotland has recorded 24 deaths from coronavirus and 500 positive tests in the past 24 hours, she confirmed, bringing the death toll under this measure – of people who first tested positive for the virus within the previous 28 days – to 7,398.

There are 726 people in hospital confirmed to have the virus, down 24 in 24 hours, and 69 patients are in intensive care, down one.

She said the daily test positivity rate is 2.5%, down from 2.6% the previous day.

Speaking ahead of First Minister’s Questions, Ms Sturgeon said: “There is little doubt at the moment that things are heading in the right direction.

“The number of cases is falling, the numbers in hospital are falling and vaccination programme is progressing extremely well.”

She said there is “much to feel optimistic about” but urged people to continue with caution and comply with stay-at-home regulations and other mitigation measures.

Giving an update on the vaccination programme, she said 1,688,808 people have received a first dose as of Wednesday morning – up by 26,729 – and 100,058 have received their second dose.

She added 95% of people aged 65-69 have had the initial inoculation, as have 37% of people aged 60-64, 31% of 55-59 year olds, and 26% of those aged 50-54.

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Meanwhile, Nicola Sturgeon has told MSPs she wants to get on with the job of leading Scotland out of the coronavirus pandemic, after spending eight hours answering questions on her Government’s botched investigation of misconduct allegations against Alex Salmond.

The Scottish First Minister spent Wednesday in front of a Scottish Government committee set up to examine how those complaints were dealt with.

Ms Sturgeon made clear that after her lengthy session in front of the committee on Wednesday, she now wants to move on.

She said: “I answered questions for eight hours on this yesterday. I answered every question that was put to me.

“So I intend now to rest on that, to allow both the committee and the inquiry on the ministerial code to conclude their work.

“In the meantime I am going to get on with doing the job I suspect most people watching at home right now want me to get on with – which is leading this country through and out of a pandemic.

“I will leave Ruth Davidson and the Conservatives to play the political games that they seem to prioritise over everything else.”

New Covid-19 vaccine to tackle variants

It comes as Matt Hancock revealed in Glasgow today that the UK could become one of the fastest countries in the world to approve new Covid-19 vaccines to tackle variants.

Health Secretary Matt Hancock said the Medicines and Healthcare products Regulatory Agency (MHRA) will oversee a fast-track approach to approving new jabs, after studies suggested variants may make vaccines less effective.

During a visit to the Glasgow lighthouse lab, Mr Hancock said: “We will have a fast-track approach to safely approving future vaccines that work against a variant of Covid-19.

“The vaccine programme has clearly been a huge UK success story, and part of the reason that we have been able to develop the vaccines so far, so quickly, is because of the MHRA’s rigorous yet flexible approach, which has been based entirely on looking as quickly as possible at the safety and efficacy of vaccines.

“I’m delighted that they’re taking that same principled approach to the approval process for vaccines that may work against variants.”

Scientists have become concerned about several variants, including one first identified in the Brazilian city of Manaus.

A study this week suggested that between 25% and 61% of people in the city who had previously had Covid were susceptible to reinfection with the worrying P1 variant found there.

Six cases of P1 have been found in the UK to date – three in England and three in Scotland.

Vaccine manufacturers including Pfizer and AstraZeneca are already working on new jabs to tackle variants in case they are needed.

MHRA chief executive Dr June Raine said the new approval process is “agile”, and the green light for new jabs could be given in just a few weeks after all data has been submitted on their effectiveness.

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She insisted no corners would be cut on safety, and the framework already exists for when annual flu jabs are tweaked.

She said: “Has this approach been done before? This approach that we’re putting out today for the Covid-19 vaccines is based on the tried and tested regulatory process which is used every year for seasonal flu jabs.”

She said that by carrying out a “real-time” rolling review of evidence, as was done for the original Covid-19 vaccines, the MHRA’s approval would come “in a very efficient manner, as short as a couple of weeks”.

Asked about whether the UK would offer quicker approval than some other countries, she said: “You will be aware that there are other major jurisdictions, the FDA (in the US) and the European Medicines Agency, and this guideline we feel is more flexible and more capable of moving in an agile way, depending on the format of the vaccine, and the data we already hold.

“You’ll be aware that the data we hold in the UK, having been agile initially, is a very substantial set of data.”

The MHRA has joined forces with regulators in Australia, Canada, Singapore and Switzerland as part of the ACCESS Consortium, which has issued new guidance on rapid approval.

Dr Raine said the focus at the MHRA “is to make sure that innovation reaches patients in the shortest time”, with the “hallmark” of the latest guidance being “scientific flexibility”.

She added: “Our flexible guideline is what we believe will enable us to adapt very quickly to changing situations which, as we know, can change very fast.”

The MHRA has said researchers can measure protection by looking at antibodies in the blood after vaccination, reducing the need to wait and see whether people in a clinical trial become infected with the virus.

This will significantly reduce the time it takes for the modified vaccine to be ready, with new trials involving perhaps just a few hundred people.

Dr Christian Schneider, chief scientific officer at the MHRA, said: “The public should be confident that no vaccine would be approved unless the expected high standards of safety, quality and effectiveness are met.

“Our priority is to get effective vaccines to the public in as short a time as possible, without compromising on safety. Should any modifications to authorised Covid-19 vaccines be necessary, this regulatory approach should help to do just that.”