SCIENTISTS have harnessed the power of a woman’s hyper-sensitive sense of smell to develop a test to determine whether people have Parkinson’s disease.

The test has been years in the making after academics realised that Joy Milne could smell the condition.

The 72-year-old from Perth has a rare condition which gives her a heightened sense of smell.

She noticed that her late husband Les developed a different odour when he was 33 – some 12 years before he was diagnosed with the disease, which leads to parts of the brain become progressively damaged over many years.

Mrs Milne, dubbed “the woman who can smell Parkinson’s” described a “musky” aroma, different from his normal smell.

Her observation piqued the interest of scientists who decided to research what she could smell, and whether this could be harnessed to help identify people with the neurological condition.

Years later, academics at the University of Manchester have made a breakthrough, by developing a test which can identify people with Parkinson’s disease using a simple cotton bud run along the back of the neck.

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Researchers can examine the sample to identify molecules linked to the disease to help diagnose whether someone has the disease.

While still in the early phases of research, scientists are excited about the prospect of the NHS being able to deploy a simple test for the disease.

There is currently no definitive test for Parkinson’s disease, with diagnosis based on a patient’s symptoms and medical history. If the new skin swab is successful outside laboratory conditions, it could be rolled out to achieve faster diagnosis.

Mrs Milne said that it was “not acceptable” that people with Parkinson’s had such high degrees of neurological damage at the time of diagnosis, adding: “I think it has to be detected far earlier – the same as cancer and diabetes, earlier diagnosis means far more efficient treatment and a better lifestyle for people. It has been found that exercise and change of diet can make a phenomenal difference.”

She said her husband, a former doctor, was “determined” to find the right researcher to examine the link between odour and Parkinson’s and they sought out Dr Tilo Kunath at the University of Edinburgh in 2012.

Dr Kunath paired up with Professor Perdita Barran to examine Mrs Milne’s sense of smell.

The scientists believed that the scent may be caused by a chemical change in skin oil, known as sebum, that is triggered by the disease.

In their preliminary work they asked Mrs Milne to smell T-shirts worn by people who have Parkinson’s and those who did not. Mrs Milne correctly identified the T-shirts worn by Parkinson’s patients but she also said that one from the group of people without Parkinson’s smelled like the disease – and eight months later the individual who wore the T-shirt was diagnosed with Parkinson’s.

Researchers hope the finding could lead to a test being developed to detect Parkinson’s, working under the assumption that if they were able to identify a unique chemical signature in the skin linked to Parkinson’s, they may eventually be able to diagnose the condition from simple skin swabs.

In 2019, researchers at the University of Manchester, led by Prof Barran, announced that they had identified molecules linked to the disease found in skin swabs.

The scientists have now developed a test using this information, which has been successfully conducted in research labs and are assessing whether they can be used in hospital settings.

If successful, the test could potentially be used in the NHS so GPs can refer patients for Parkinson’s tests.

The findings detail how sebum can be analysed with mass spectrometry – a method which weighs molecules – to identify the disease.

Some molecules are present only in people who have Parkinson’s disease.

Researchers compared swabs from 79 people with Parkinson’s with a healthy control group of 71 people.

Prof Barran said: “There are no cures for Parkinson’s, but a confirmatory diagnostic would allow them to get the right treatment and get the drugs that will help to alleviate their symptoms. There would also be non-pharmaceutical interventions, including movement and also nutritional classes, which can help. And I think most critically, it will allow them to have a confirmed diagnosis.”

Mrs Milne is now working with scientists to see if she can smell other diseases such cancer and tuberculosis.

But said that she can sometimes smell people who have Parkinson’s while in the supermarket or walking down the street but has been told by medical ethicists she cannot tell them.

“Which GP would accept a man or a woman walking in saying ‘the woman who smells Parkinson’s has told me I have it’?

“Maybe in the future but not now.”