John Swinney used his first speech to SNP conference to pay tribute to his wife and son, saying that he was only to take on the job as First Minister thanks to the sacrifice of his family.
Elizabeth, who is a BBC Scotland reporter, has secondary progressive Multiple Sclerosis.
There was a standing ovation from delegates in the hall at the Edinburgh conference centre, as Mr Swinney thanked his spouse.
The First Minister told delegates: "Before I could respond to the many calls from across this Party for me to stand for leadership, I had to be certain that those I love would be alright if I was First Minister.
"As many of you know my wife Elizabeth has Multiple Sclerosis. Elizabeth’s condition is something that affects our lives every minute of every day.
"We have to make plans, we have to make adjustments, we have to sometimes accept that some things are just not possible to do.
"But despite all of that, Elizabeth remains determined that her condition should not stop her – and those around her - from living life to the full.
"I can only lead this Party, and be First Minister of Scotland, because Elizabeth is prepared to make the sacrifice of not having her husband around quite as much as she probably needs.
"So to Elizabeth, thank you for giving so much so I can serve our country."
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