The computer scientist will deliver the keynote speech to ScotSoft 2013, an event hosted by trade body ScotlandIS.
Mr Cerf will also meet 250 Scottish teenagers who grew up with the internet.
The ScotSoft Global Forum, which runs alongside the ScotSoft awards dinner, will also feature talks from Larry Cable, chief architect of Salesforce, and four of Silicon Valley's most powerful female investors and entrepreneurs: Heidi Roizen, Karen White, Ann Winblad and Wendy Lea.
Mr Cable will use his address to explore current and upcoming trends in Silicon Valley.
He will look at how companies are innovating and delivering mobile applications from the cloud, accessing big data and using open source technologies to accelerate time to market and reduce capital investment.
The industry in Scotland will be represented at the forum by Eddie Anderson, founder of Pentech Ventures, and John Innes, chief executive of Amor Group.
As part of the forum, staff from eight of Scotland's brightest start-ups will take part in one to one mentoring sessions at Informatic Ventures.
Participating in the sessions will be Ms Roizen, venture partner at DFJ, Ms White, chairman and chief executive of Syncplicity, Ms Winblad, co-founder and managing director of Hummer Winblad Venture Partners, and Ms Lea, chief executive of Get Satisfaction.
Taking place at The Sheraton Grand Hotel, the conference is expected to attract an audience of 400 delegates.
Polly Purvis, executive director of ScotlandIS, said: "We are extremely proud to bring together leading technology entrepreneurs and VCs (venture capitalists) from both sides of the Atlantic to share the experiences and lessons they have learnt at the sharp end of entrepreneurialism."