Researchers at the University of Glasgow have discovered a way to make swallowable cameras more effective at detecting throat and gut cancers.
Devices small enough to be swallowed by patients have provided a valuable alternaitve to more intrusive imaging methods like endoscopes in recent years.
However, the systems, known as video pills, have relied on using a small light source to illuminate the area being examined by doctors.
Researchers at Glasgow University's School of Engineering have now found a way to use fluorescent lights to create flurorescence imaging in the pills for the first time.
Flurorescence imaging is already a powerful diagnostic tool in medicine. However, it has previously used a lot of power and been expensive and bulky.
Research Associate, Dr Mohammed Al-Rawhani said: “The system we’ve developed is small enough and power efficient enough to image the entire human gastrointestinal tract for up to 14 hours.
“We’ve confirmed in the lab the ability of the system to image fluorescence ‘phantoms’ – mixtures of flavins and haemoglobins which mimic closely how cancers are affected by fluorescence in parts of the body like the intestines, the bowel and the aesophagus.
“The system could also be used to help track antibodies used to label cancer in the human body, creating a new way to detect of cancer.
“It’s a valuable new technique which could help clinicians make fewer false positives and negatives in cancer diagnosis, which could lead to more effective treatment in the future.”
The project was led by Professor David Cumming in Electronic and Nanoscale Engineering at the University of Glasgow.
Professor Cumming said: “We’ve played an important role in developing the technology behind video-pill systems, and this is an exciting new development, which offers a valuable new resource for gastrointestinal imaging.
“There’s still some way to go before it will be ready for commercial production and clinical use, but we’re in early talks with industry to bring a product to market. We’re also interested in expanding the imaging capabilities of video-pill systems to new areas such as ultrasound in the near future.”
The paper, titled ‘Wireless fluorescence capsule for endoscopy using single photon-based detection’ is published in Scientific Reports and is available at www.nature.com/articles/srep18591
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