What's The Point Of It? is the first retrospective of work by Martin Creed, the British artist who shot to fame when he controversially won the Turner Prize in 2001 for showing lights going on and off in an empty room.
A collection of nails hammered into the gallery wall, cactus plants, and black curtains which open and close are among the 160 works on display at the Southbank Centre's Hayward Gallery.
In one installation, visitors can walk into a room filled with 6,000 large white balloons and attempt to find their way through them to the other side.
One of Creed's newest works is a silver Ford Focus, which the artist, who grew up in Glasgow, has displayed on the gallery terrace.
Every few minutes the engine switches on, the horn sounds, the doors and bonnet open, the windscreen wipers move from side to side and the radio blasts, before it all goes off again.
Other new works include a structure made from hundreds of peach-coloured toilet rolls and a huge wall comprised of 16,000 bricks.
A series of 1,000 colour prints, made between 2009-10 from broccoli, goes on show in the UK for the first time.
A giant rotating neon and steel structure, which stands just above head height, spells out the word Mothers.
On one terrace, set against the backdrop of the London skyline, a video screen shows a man's penis getting erect then drooping again.
The gallery warns that the work, created between 2007-10, is for over-18s.
Another warning sign greets visitors before they enter a room to see a 2007 work, a video of a woman defecating on a white floor.
Creed said that he was "scared" that he would not like his own retrospective.
He said: "When I was at art school, a tutor said 'never show all your work, always keep something back, so at least if they don't like it you can go home and say well they didn't like that but they might have liked this'.
"This show is a collection of pretty much all the things I've been doing in my life apart from watching TV."
Creed said that he was trying to battle against his own prejudices and his taste for "conventional stuff", adding: "I always feel like I failed to do that, that's why I'm wearing shoes."
Southbank Centre artistic director Jude Kelly said that the exhibition would entice "many different kinds of audiences", adding: "Martin is one of the key people who has made people turn to the visual arts."
Events to coincide with the exhibition include a performance from the Martin Creed Band at the Royal Festival Hall on February 8 and the premiere of his new organ commission on March 30.
:: Martin Creed: What's The Point Of It? runs at the Hayward Gallery, Southbank Centre from January 29 to April 27.