Building firm Downing has been given permission to build two 10-storey buildings on Beith Street, on the site of the former Partick railway station.
The development will provide 701 en-suite flats, with students sharing kitchen and lounge facilities. Landscaped gardens will overlook the River Kelvin.
The development, which has been designed by architects Falconer Chester Hall, is part of the wider Glasgow harbour redevelopment.
Work is scheduled to finish in time for the new academic year in September 2015; and rent prices will be released this December.
A Downing spokesman said: "Glasgow is an exciting city with a burgeoning student population and we're delighted to be making strides on this ambitious scheme, which will revitalise this area and help to address the pressing need for quality student accommodation in the city."
Downing is delivering £200m worth of schemes across the UK, including a student accommodation scheme in Leeds, and projects in Newcastle, Cambridge and Liverpool.