Dave Frey, who works for Ramones Productions and Silent Partner Management, says Ramone's wife called to tell him he died yesterday.
Tommy Ramone, a drummer, co-founded the Ramones in 1974 in New York along with singer Joey Ramone, bassist DeeDee Ramone and guitarist Johnny Ramone.
All four band members had different last names, but took the common name Ramone.
The band influenced a generation of rockers, and their hit songs I wanna be sedated and Blitzkrieg Bop, among others, earned them an induction into the Rock and Roll Hall of Fame in 2002.
Though they never had a Top 40 song, the Ramones influenced scores of followers, including Green Day and Nirvana.
The Ramones' best-known songs reflected their twisted teen years: Beat on the Brat, Now I Wanna Sniff Some Glue, Teenage Lobotomy and Sheena Is a Punk Rocker.
The Ramones disbanded in 1996 after a tour that followed their final studio album, Adios Amigos. A live farewell tour album, We're Outta Here!, was released in 1997.
Johnny Ramone, whose birth name was John Cummings, died in 2004 of prostate cancer. Joey Ramone (Jeff Hyman) died in 2001 of lymphatic cancer. Dee Dee Ramone (Douglas Colvin) died from a drug overdose in 2002.