Malta-based director Herman Grech is in discussions with writer Alan Clark about presenting The Lockerbie Bomber in Valletta later this year.
Mr Grech said: "The play struck me because it recalls the bombing of the aircraft in its vivid, horrific detail.
"But most of all, the script challenges the audience into thinking whether this could have been one of the grossest miscarriages of justice of our times."
He said he found it ironic that while the Maltese government claims the bomber never departed from the island's airport, it is still reluctant to challenge accusations against Abdelbaset Ali Mohmed al Megrahi, the Libyan convicted of the bombing.
Alan Clark said: "Mr Grech and I have had preliminary discussions about performances in Malta. It's especially interesting because Malta has particular relevance to Lockerbie, an angle the play examines.
"The Maltese shopkeeper Tony Gauci identified Megrahi - as resembling the man who bought clothes in his shop."
Dr Jim Swire, whose daughter Flora died in the attack, said: "I welcome the play as it tries to shed light on what happened when the investigation went off the rails."
Tryst Theatre is staging the play in Alloa's Alman Theatre from January 17-19.