A number of bottles of "unusual" whisky were taken from the Glenglassaugh distillery in Portsoy, Aberdeenshire, during the incident which happened between 4.30pm on Tuesday and 9.30am yesterday.
Among the bottles taken were 37-year-old and 40-year-old Glenglassaugh malt whiskies.
Four pot stills and a number of Lyle & Scott jumpers are also missing following the break-in.
Constable Geraint Kalies said: "This is a very unusual theft and I am appealing for any witnesses who may have any information regarding the identity of the persons responsible.
"I would also ask that anyone who is offered whisky or clothing branded with Glenglassaugh distillery should contact Police Scotland on 101 or Crimestoppers anonymously on 0800 555 111."