The budget airline said the move will be part of plans to cut capacity at Luton by 20% and pull out of its base altogether at East Midlands airport on January 5.
EasyJet has been carrying out a 90 day consultation process with staff and promised to accommodate all 107 affected cabin crew and pilots who wish to move to its other bases.
Passengers booked to travel after January 5 will be emailed over the next few days and offered either a free transfer to another easyJet flight, a free transfer to a bmibaby flight, or a full refund.
A company spokesman plans to move the capacity to more profitable airports, and is still committed to an overall growth plan of 7.5% per year over the medium term.
The 20% reduction from Luton will see the airline cease to operate routes to Athens, Cagliari and Vienna from Luton, as well as reduced frequencies on routes including Alicante, Dortmund, Edinburgh, Geneva, Glasgow, Nice and Paris.
The spokesman said the company had managed to achieve a reduction of 20% in its flying programme, whilst protecting its cabin crew and pilots from potential redundancy, by flying more flights on behalf of other airports and reducing the number of services from other bases to Luton.
He adde the number of based aircraft at Luton will remain at 16, the spokesman, but departing passenger volumes will fall to 1.9m, down from 2.6m in 2008.
The strategy is also hoped to protect the airline's position at Luton.
East Midlands Airport managing director Penny Coates said: "We are naturally disappointed to hear that easyJet will leave the East Midlands region in 2010, but our passengers will be pleased to hear that all of the routes operated by easyJet are still available with other low cost carriers.
"That's why we welcome the new routes recently announced by bmibaby and the option for passengers to easily transfer flights already booked with easyJet to bmibaby.
"We will continue to work with easyJet to ensure all of our customers experience minimal disruption to any bookings and hope the many loyal passengers that have travelled with easyJet from East Midlands Airport, will continue to choose other carriers from the airport.”
EasyJet operated 10 routes from East Midlands Airport - Prague, Nice, Venice, Faro, Barcelona, Alicante, Malaga, Ibiza, Palma and Geneva.
The airport said it had not lost any destinations and all 10 routes will continue to be operated by other low-cost carriers.
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