Wildlife authorities said it is likely the pair spawned pups, and if confirmed, the rare predators would be the first breeding pair of wolves in the north-western state's Cascade Range since the early 1900s.
Officials said cameras in the southern Cascades captured several images of what appears to be a female wolf in the same area where OR-7's GPS collar shows he has been living.
US fish and wildlife service biologist John Stephenson said it is not proof, but it is probable the two wolves mated over the winter and are rearing pups that would have been born in April.
Biologists will not start looking for a den until June, to avoid endangering the pups.
"It's amazing that he appears to have found a mate," Mr Stephenson said. "I didn't think it would happen. It makes me more impressed with the ability of wolves to survive and find one another."
Young wolves typically leave their pack and strike out for a new territory, hoping to find a mate and start a new pack.
OR-7 has been looking for a mate since leaving the Imnaha pack in north-eastern Oregon in September 2011.
His travels have taken him thousands of miles as he crossed highways, deserts and ranches in Oregon, moved down the spine of the Cascade Range deep into Northern California and then back to Oregon, all without getting shot, having an accident or starving.
Along the way, he was photographed by a hunter's trail camera in the Cascades outside Medford and by a biologist informing ranchers in Northern California he was in the area.
Federal Endangered Species Act protections for wolves have been lifted in eastern Oregon, where the bulk of them reside, but they remain in force in the Cascades.
Protections for the animals have also ended in the last several years in the Northern Rockies and western Great Lakes.
The US fish and wildlife service has proposed ending the listing across most of the rest of the country as populations have rebounded. A final decision is expected later this year.
Officials had planned to let OR-7's GPS collar die, but now that he appears to have found a mate, he will be fitted with a new one this summer to monitor the pack.