The crackdown was set out by the Chancellor George Osborne earlier this week and will see JSA claimants forced to attend job centres daily or lose their payments.
"No attendance. No benefit. That is only fair," the Work and Pensions Secretary will say.
Earlier Mr Osborne had batted away questions over how ministers would sanction those with dependents.
Mr Duncan Smith will outline plans for two trial projects to begin next year. These will force jobseekers to attend a local centre 35 hours a week for six months for expert support and supervision or lose their benefits. One pilot will target the very long-term unemployed, and the other will provide targeted early help.
Mr Duncan Smith is expected to say: "For those who aren't doing all they could, or who we think are cheating the system, it is time to make very clear that enough is enough."